Optimization of the synthesis, in silico ADME/Tox profiling studies, and evaluation of the antimalarial activity of (7-chloroquinolin-4-ylthio)alkylbenzoate derivatives

Optimized reaction conditions are developed to obtain a series of [(7-chloroquinolin-4-yl)sulfanyl] alcohol derivatives as intermediates prepare range (7-chloroquinolin-4-ylthio) alkylbenzoate derivatives. The structures all the synthesized compounds confirmed from their infrared and nuclear magnetic resonance spectral data, by elemental analysis. In silico ADME/Tox profiling studies molecules undertaken, potential antimalarial activity products is determined. vitro, prepared significantly reduce heme crystallization with IC 50 values < 10 µM. vivo, reduction in parasitemia levels survival time increases marginal.